Cell biology processes: model building and validation using quantitative data

Part of the applied mathematics seminar series.

Cell biology processes such as motility, proliferation and death are essential to a host of phenomena such as development, wound healing and tumour invasion, and a huge number of different modelling approaches have been applied to study them. In this talk I will explore a suite of related models for the growth and invasion of cell populations. These models take into account different levels of detail on the spatial locations of cells and, as a result, their predictions can differ depending on the relative magnitudes of the various model parameters. To this end, I will discuss how one might determine the applicability of each of these models, and the extent to which inference techniques can be used to estimate their parameters, using both cell- and population-level quantitative data.