Dr Toni Lassila

Profile

Toni has a doctoral degree in Mathematics with expertise in numerical methods in cardiovascular modelling, reduced order models, and uncertainty quantification. He has previously worked at the Ecole Polytechnique Federale de Lausanne and the University of Sheffield, before joining the University of Leeds in August 2018. He has co-supervised five PhD students in the past, and has been involved with several European projects (ERC and FP7/H2020).

Responsibilities

• Lead for Industrial Placement Year in School of Computer Science

Research interests

Toni's research interests are in the field of numerical methods for partial differential equations, specifically within the topics of reduced order models and uncertainty quantification. Applications of these methods can be found in the computational fluid dynamics simulations for the diagnosis and treatment of cardiovascular and cerebrovascular diseases. In the past, he has worked on the modelling of cardiovascular system, both in terms of the electrophysiology and the ventricular fluid dynamics. His current work focuses on combining patient-specific imaging and sensing with mathematical modelling to enhance the diagnosis and treatment of vascular diseases, while taking into account the physiological variability of vascular flow and its effects in the simulation model predictions. More recently, he is working on techniques for in-silico trials, meaning the generation of evidence through computational simulations on virtual patients to support the medical device R&D and approval process. He is also interested in deep learning generative models in synthetic image generation, and physics-informed neural networks for accelerating the simulation of cardiovascular problems.

• Deep Learning with Simulated Data

Qualifications

• M.Sc.
• DSc. (Tech.)

Professional memberships

• IEEE (Institute of Electrical and Electronics Engineers)

Student education

I am available to supervise self-funded or externally-funded PhD projects e.g. on the following topics (details to be discussed with the candidate):

• “Generative machine learning models for the cerebral vasculature from large-scale imaging and clinical studies”
• “Physics-informed neural networks and model discovery for cardiac mechanics”
• “Vascular flow simulation directly from medical images to support automated workflows for in-silico trials”

If you are motivated student with a computer science MSc and a strong track record and are looking for funding to do a PhD project, please contact me to discuss possible funding sources that you could apply for.

Research groups and institutes

• Computing in Biology, Medicine and Health
• Artificial Intelligence
• Computational Science and Engineering

Current postgraduate researchers

• Michael MacRaild

Projects

<li><a href="//phd.leeds.ac.uk/project/2150-medical-image-synthesis-using-generative-machine-learning-models-for-testing-public-health-hypotheses-related-to-ischemic-stroke-risk">Medical image synthesis using generative machine learning models for testing public health hypotheses related to ischemic stroke risk</a></li>