Innate Immunity and the Nanoscale Matters
- Date: Wednesday 31 October 2018, 14:00 – 15:00
- Location: Roger Stevens LT 06 (8.06)
- Type: Seminars, Physics and Astronomy
- Cost: Free
Professor Moein Moghimi, Newcastle University. Part of the condensed matter group research seminar series.
Professor Moein Moghimi, from the School of Pharmacy, Newcastle University, will be presenting a seminar on his research. All are welcome to attend.
Man-made nanoparticles and nanopharmaceuticals, by virtue of their size, shape and surface properties may resemble pathogens and these properties makes them prone for interception by different components of the innate immunity such as blood leukocytes, tissue macrophages and the complement system following entry into the body. The outcome, however, may be different and include safe elimination or escape, immune stimulation, immune suppression and complex adverse injection-related cardiopulmonary distress, depending on physicochemical characteristics of nanoparticles, quantity and frequency of the administered dose as well as the portal of entry. This presentation will evaluate the dynamic interplay between nanoparticle characteristics and the innate immune responses in relation to the development of personalized nanomedicines through “immune safe-by-design” paradigm.
ACS Nano (2018) 12: 5834; Drug Discov. Today (2018), 23: 1034; Semin. Immunol. (2017) 34: 33; Nature Nanotechnol. (2017) 12: 589; Nature Nanotechnol. (2017) 12: 387; ACS Nano (2017) 11: 12; J Control. Release (2016) 239: 1; Biomaterials (2016) 78: 20; ACS Nano (2015) 9: 10758; ACS Nano (2013) 7: 1108; Annu. Rev. Pharmacol. Toxicol. (2012) 52: 481; J. Innate Immun. (2012) 4: 509; ACS Nano (2011) 5: 8454; ACS Nano (2010) 4: 6629.
For further details please contact Dr Zhan Ong.