Kwan Choi Kwan (Raymond)
- Email: email@example.com
- Thesis title: Engineering Mechanically Competent Constructs for Cartilage Repair
I completed a MEng (Hons) in biomedical materials science at the University of Manchester.
Cartilage has limited repair capacity; any damage untreated could worsen and eventually leads to osteoarthritis. One possible strategy is to implant a functional tissue engineered construct as a replacement for the damaged cartilage. A new method has been recently devised that uses compressive loading to generate constructs with similar mechanical and histochemical properties to native cartilage. Utilising this method, the project aim is to improve efficacy of construct development, accelerating clinical translation. Chondrocytes synthesise a cartilage extracellular matrix (ECM) that confers functional properties in response to their mechanical environment. The project objective is to determine whether a specific range of cellular deformation promotes optimal deposition of “quality” cartilage-like ECM in maturing constructs. In addition, the corresponding overall construct strain used to produce desired cellular deformation will be defined.
- MEng (Hons) in Biomedical Materials Science
Research groups and institutes
- Institute of Medical and Biological Engineering