Dr. David Marples


I trained in medicine in Oxford, and did my first PhD (actually a DPhil – Oxford has to be different!), completing both in 1990. After my house jobs, I did a renal physiology post-doc in Oxford, before going to work as an associate professor with Soren Nielsen in Aarhus for two years, studying the newly-emerging group of aquaporin water channels. In 1996 I moved to Leeds as a University Research Fellow, becoming a Lecturer in 2001 and a Senior Lecturer in 2006. I ran a research group looking at (mainly renal) aquaporins and water balance disorders, but gradually also acquired a range of teaching and admin responsibilities, including in quantitative physiology and anatomy. From 2010 to 204 I was programme lead for the Medical Sciences programme, and from 2014-2019 I was Director of Student Education for the Biomedical Sciences group of programmes. 

I have substantial experience in light and electron microscopy, western blotting and cell culture, as well as whole-animal physiology.

From 2019 to 2023 I held a PwC degree apprenticeship to study Computer Science (Digital and Technology Solutions), obtaining a First Class degree, and a distinction in the Apprenticeship as a data analyst. I have experience in programming in C, C++, Java, and (preferably) Python.

Research interests

Renal physiology, especially water balance disorders such as nephrogenic diabetes insipidus and SIADH.

Aquaporins more generally, including a little on their role in tumour invasion and metastasis.

Integrated systems physiology.

Artificial Intelligence.


  • MA Physiological Sciences (Oxon)
  • DPhil (Oxon)
  • BM /BCh (Oxon) (medical doctor)
  • FHEA (Leeds)
  • BSc Computer Science (Leeds)