Dr Zhan Yuin Ong
- PDRA mentoring scheme coordinator
I have a strong interest in the development and translation of innovative biomaterials to advance the therapy of human diseases with unmet clinical needs. The research in my group focuses on the synthesis of well-defined and biocompatible hybrid organic-inorganic nanoparticles, and their directed assembly into more complex micron-scale materials with unique functionalities for drug delivery applications. Our approach is highly interdisciplinary in nature, encompassing materials synthesis and characterisation, anticancer and antimicrobial evaluation, biocompatibility testing, with key clinical collaborations to address global health challenges. Current research areas include:
Synthesis of Multifunctional Hybrid Organic-Inorganic Nanomaterials. We are interested in developing simple and scalable synthetic methods to obtain highly uniform porous silica nanoparticles and anisotropic gold nanoparticles with desirable built-in functionalities such as cancer targeting, and stimuli-responsive properties for biomedical applications.
Targeted Drug Delivery and Photothermal Therapy of Cancer. We utilise the multifunctional nanomaterials for drug loading and release in response to changes in the tumour microenvironment. The intrinsic cancer targeting properties of the hybrid nanoparticles are evaluated using human cancer cells. With the ability to promote selective uptake of nanoparticles by cancer cells but not in non-cancerous cells, enhanced anticancer drug delivery and photothermal ablation of cancer cells are observed.
Stimuli-responsive Delivery of Antimicrobial Agents to Overcome Antimicrobial Resistance. We are interested to enhance the bioavailability of novel antimicrobial agents such as antimicrobial peptides through unique formulation approaches. By harnessing the strong optical properties of gold nanoparticles, triggered release of antimicrobial agents from hydrogels can be achieved in a spatial and temporal manner.
Funders: EPSRC, Royal Society, British Council.
We welcome enquiries from prospective postdoctoral fellowship applicants (e.g. to RAEng, Newton International Fellowships, Marie Skłodowska-Curie Actions).
- PhD in Pharmaceutical Science
- BSc (Pharm) (Hons)
- Royal Society of Chemistry (MRSC)
- British Society of Antimicrobial Chemotherapy
- Society of Applied Microbiology
I am currently a personal tutor for undergraduate students and lecture at Levels 1 and 5. I also supervise BSc, MPhys, Medicine MRes, and PhD students.
Research groups and institutes
- Molecular and Nanoscale Physics
<li><a href="//phd.leeds.ac.uk/project/352-multifunctional-hybrid-porous-silica-nanoparticles-for-stimuli-responsive-delivery-of-novel-antimicrobial-agents">Multifunctional hybrid porous silica nanoparticles for stimuli-responsive delivery of novel antimicrobial agents</a></li>
<li><a href="//phd.leeds.ac.uk/project/837-novel-nanoparticle-loaded-formulations-to-enhance-the-locoregional-delivery-of-anticancer-drugs-to-brain-tumours">Novel nanoparticle-loaded formulations to enhance the locoregional delivery of anticancer drugs to brain tumours</a></li>